The Chemistry of Addiction


Part of what makes our brains so deliciously amazing, is that they’ve evolved to reward us and encourage us when we do stuff that helps us survive and spread our genes all over the place. I’m talking about eating and sex having and running from danger. Stuff like that. For hundreds of thousands of years, this system served us well. But in a way, our brains have since gotten too smart for their own good. We’ve figured out how to make ourselves experience this pleasure when we’re not even doing any of those things. By inventing drugs. And we’ve also figured out how we could do those things. Eating, sex having, getting an adrenaline rush. Recreationally. Instead of for our survival. And sometimes the craving for that feeling can take on a life of its own. And so, by doing these things, we have basically invented addiction. Nice move, brains. But this is why addiction isn’t limited to drugs; behaviors can be addictive too. The compulsive urge to use cocaine again and again, the compulsive urge to eat candy bars again and again, are both produced from the same brain circuitry. Same goes for addictions to gambling, sex, eating, even…Reddit. Addiction: it’s all in our brains. Mo’ synapses, mo’ problems. [Intro Jingle] The chemistry of addiction takes place mostly in the brain’s limbic system, the set of structures at the center of the brain that controls our emotional and behavioral responses to the information we receive. It’s often referred to as the brain’s “reward center.” And it responds to new information from the nervous system by releasing chemical messengers called neurotransmitters that pass signals from one neuron to the next or to another kind of cell it wants to activate. Your brain produces at least 100 different neurotransmitters and we’re finding new ones all the time. But the most important neurotransmitters, when it comes to addiction, are the ones that are released when we do something that’s key to our survival and success. Once they’re done getting the word out, they’re usually re-absorbed back into whatever neurons they originated from. There are two major kinds of neurotransmitters and in a healthy brain they’re pretty much in balance. There’s excitatory neurotransmitters, which get their target cells all fired up with chemical energy and there’s inhibitory neurotransmitters which keep their target cells calm and mellow. Serotonin is an inhibitory neurotransmitter that you’ve probably heard of; it helps regulate your mood, your your appetite and your sleep cycle. But it’s the excitatory ones that you really gotta watch out for. Endorphin, for instance, is released when we exercise, are really stressed or in a lot of physical pain, and it helps with coping and painkilling. And, by far, the most important reward chemical is dopamine. It’s released whenever our brain believes we should take strong note of our current behavior, to remember it. It’s levels rise in response to pleasurable experience like eating or baby-making. But it’s also released when, like, a bull moose is charging us. PAY ATTENTION TO THIS MOMENT! DO NOT FORGET IT! So, yes, the exciting sensation you feel when your dopamine levels are up reminds our brains to do things that are important to our survival. But it’s also a large part of what drives addiction. Because addictive drugs are really good at not only messing with our levels of dopamine and other neurotransmitters, they also exploit the brain’s ability to vividly remember unnatural highs and motivate itself to find more of them in the future. Scientists have recently started to debate whether dopamine actually makes you feel good, or if it just exists to make you want things more. We’ve always based the assumption that dopamine makes you feel good on the fact that it makes people and, more commonly, rats repeat activities that increase dopamine levels. But while dopamine definitely has a pleasure component, it may be much more important in simply creating desire, whether or not there’s a pleasurable outcome, which is why, maybe, so many addictions continue long after any actual pleasure is gone. Another important factor in addiction is that when the brain is met with the intense stimuli that drugs can cause, it has all kinds of defenses that it desperately uses to restore balance. So after using a certain drug over the long-term, your brain will reduce the number of neurotransmitters or receptors available to it to try to moderate it’s effects. This leads to what’s known as a hypo-functioning reward system, which makes artifical and natural highs harder to come by. So while your brain on drugs is not technically a fried egg, it is a significantly altered egg. This is why we develop tolerance to certain drugs and why addicts often end up with shiny new psychological disorders they didn’t have before their addictions. Now, with all this in mind, drugs that cause addiction screw with your brain activity in two major ways: One, they imitate one of your natural neurotransmitters or two, they artificially change the levels of your neurotransmitters, either by overstimulating their release or inhibiting their re-absorption. So, for instance, heroin and other opiates like codeine and morphine are some of the most addictive substances on Earth, because their structure is very similar to endorphin. They bind to nerve cell receptors reserved for endorphin in huge numbers which magnifies endorphin’s painkilling effect, creating a feeling of euphoria. Opiates create far more powerful reactions than any natural stimulus. So once the artificial high is experienced, the brain craves to return to that feeling. Nicotine, meanwhile, takes a different attack vector; first, it mimics a neurotransmitter called acetylcholine which triggers the release of large amounts of dopamine. Then it also sets off the release of other chemicals that leverage it’s effect, like glutamate, which plays an important role in memory formation. So, in addition to dopamine being all, “Remember this and do it more!”, glutamate is also firing memos off to surrounding neurons, creating what some scientists think is a memory loop that reinforces the habit. Finally, a third way for it to act, nicotine also sets off a flood of an inhibitory neurotransmitter called GABA, which ordinarily calms neurons down, but after 20 minutes the GABA receptors are so desensitized that there’s nothing left to get in dopamine’s way. Then there’s alcohol, which upsets that balance of neurotransmitters that allow body and brain to function as one. It binds to a number of different receptors, including those for acetylcholine and serotonin, which explains it’s initially pleasing and, later, sedative effects. More alcohol means slower communication between neurons, but here’s the thing: as the brain grows used to alcohol over long-term use it tries to compensate by releasing excitatory neurotransmitters to speed up signal transmission. So, after heavy regular drinking, if the flow of alcohol stops, the brain is left with out of control synaptic firing with nothing to calm it down. Now, you’ve heard of a drunk getting the shakes when they stop drinking. This is where that comes from. Now, some drugs don’t even bother imitating a neurotransmitter. Instead, they just screw with the levels of natural neurotransmitters. We’re talking here about things like cocaine and methamphetamine and other amphetamines like ecstasy and bath salts. Cocaine is such an effective stimulant because it interrupts the reabsorption of dopamine and another important excitatory chemical: norepinephrine. By creating extremely high concentrations of them floating around in the synapses, nerve cells are overstimulated and the user will feel pleasure from the dopamine and energy thanks to the norepinephrine. But because it creates such a flood of these neurotransmitters the cocaine ends up depleting them, and more and more cocaine is needed to produce the same high. Now, the effects of smoking meth can last up to twelve hours versus one hour to cocaine and is vicious in it’s ability to create addiction. Instead of blocking the re-absorption of dopamine, like cocaine does, meth causes the release of excess amounts of dopamine. It’s a nasty drug made worse by the fact that over time an addicts brain, in an effort of self-defense, will eventually force neurons to release an enzyme that destroys all that extra dopamine, as well as the brain’s ability to produce more. As a result, users will continue upping the dosage, seeking a high that they can’t achieve. Other new amphetamines bursting onto the scene including bath salts, which are so fascinatingly awful that we did a separate episode just on them. Bath salts contain a group of synthetic stimulants called substituted cathinones which combine the effects of both cocaine and meth at the same time. What scientists are now discovering is that these same chemical reactions brought about by substance abuse are similar to those brought about by a number of behaviors, causing behavioral addiction. Let’s take gambling: the neural circuits manipulated by wagering money on blackjack, horse racing and other games of chance are actually the same ones that originally evolved to help animals assess reward versus risk. Like, you’re living on the savannah and you haven’t eaten in two days, you don’t want to be like, “I forget, is it the black berries that kill you or the red ones?” But what researchers have discovered with gambling is that it’s not only winning that enhances dopamine transmission in the limbic system but it’s also the near misses; it’s the 4-out-of-5 jackpot symbols on the slot machine or being one number off on the roulette wheel. Those things actually have a larger effect on the brain than winning the jackpot. Almost getting the reward causes strange things to happen to the ways in which your brain anticipates future rewards. Our brains love to find and predict patterns. But, when it becomes fixed on predicting patterns in something that’s inherently unpredictable, like a slot machine, it leads to compulsive gambling. And, in fact, in 2012, the Diagnostic Statistical Manual for Mental Disorders, which is pretty much the go-to book for psychiatric illness professionals announced that it’s going to add a new category for behavioral addictions beginning with pathological gambling. It’s also adding references to internet and sex addiction for the first time and many would like to see food addiction added as well. Food and sex addiction are controversial topics, partly because of the stigmas associated with them. The release of dopamine as a response to eating fatty foods is completely natural and makes perfect sense evolutionarily. However, even this natural release of dopamine can be exploited. Studies of rats have shown that, when given easy access to high sugary and fatty foods like bacon and chocolate and cheesecake… Ooh-mmm. Bacon chocolate cheesecake. Those rats not only ignored their normal food but continued to eat the unhealthy snacks even when they were shocked in the process. Over time, the rat’s brains developed tolerance to the chemical response to junk food by desensitizing their dopamine receptors, exactly like the hypo-functioning reward circuitry caused by drug addiction. Findings like this have actually led to a theory that some people might have fewer dopamine receptors than others, which may make them more predisposed to food and other addictions. Like sex, for instance. This shouldn’t come as a surprise, given that brain scans taken during orgasm closely resemble those of heroin users after shooting up. Like food addiction, sex addiction is linked to low dopamine levels in the brain which can lead to post-sex hangovers that leave the addict in despair and on a quest to find his or her next fix. It’s a craving, both biologically and psychologically. Even here on the internet our dopamine receptors are spoiled full of fun and stimulating distractions that activate our pleasure chemicals. And like other addictive behaviors, it’s often the anticipation that’s greater than the reward. I mean really, how many times did you check your email in the last hour and how many important emails did you actually have? Meanwhile, studies of video gamers are showing that players will continue their gaming, even when multiple distractions are placed in front of them. Not that I would know anything about that. We’re living in kind of a golden age of brain research right now, which means that we’re learning more about the causes of addiction and possible cures every day. And while there pretty much is no way to avoid overstimulating your dopamine receptors in this world of instant pleasures, the rush of finding a particularly adorable cat on Reddit is likely going to remain my drug of choice, at least for the near future. Thanks for watching this episode of SciShow Infusion. Don’t do drugs. If you have any ideas for future episodes of SciShow or questions or comments you can leave them for us on Facebook or Twitter or in the comments below, and if you want to keep getting smarter with us here at SciShow, go to YouTube.com/SciShow and subscribe. We’ll see you next time. [Outro Jingle]

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100 Responses

  1. Eleanor Dobson says:

    Don't do drugs kids. Stay in school.

  2. Ken Hayashi says:

    Is this vid started at x0.75 speed?!?!?!?!?

  3. chas berg says:

    My simple words glad to hear their not monkeying around their nailing that beast!

  4. ambalam owner says:

    Make a video on the marma shastra of kalari,the Indian martial art which is said to be capable of killing in one touch

  5. Chris N says:

    Do DMT!!!

  6. Ron White says:

    So has anyone ever posted the actual ingredients in chew tobacco? I've seen articles indicating the ingredients of cigarettes.

  7. Justin Letchford says:

    You say Reddit like it's a dirty word.

  8. Lauren Doninger says:

    I wish you had not included the food/sex/shopping/Reddit piece. Gambling is currently the only non-substance addiction recognized in the DSM (though internet gaming disorder might soon be included). Binge eating disorder can be diagnosed, but it's not in the Substance-Related Addictive Disorders category. Popular media grabs hold of bits and pieces of psychology and addiction science and feeds into the lack of skepticism that plagues us; 'addict' and 'aholic' get added to all sorts of behaviors and it diminishes what the actual condition is like. I would assign this to my class, but I can't with that piece in. Generally, I really enjoy your videos.

  9. Roger Pack says:

    "hears reddit" "mmmm reddit, wonder what's on there, let me check…" 😐

  10. Mark Schwartz says:

    Nice move brain.

  11. Manolo Corsetti says:

    What you said about cathinones as acting as cocaine and meth 8s wrong

  12. The Road to Delphi says:

    Hello this show is great !!! . Can you make video on drug induces psychosis please?

  13. Kai Schreurs says:

    10:45 zero and I don't know

  14. mechasentai says:

    Dear SciShow, could you explain how people can get high from laundry detergent? I'm referring to the whole Tide Pods challenge. Also I know Tide in general is highly sought after by people who make cheap drugs. It made me wonder what drug-like properties could laundry detergent have. Thanks.

  15. I Cant Walk says:

    I worked with a guy who was addicted to cocaine. He would go to the bathroom every 10 minutes to do some. He would ALWAYS steal money from the cash registers. And if he couldn't, he would make up a lie and ask coworkers for money. Here is a tip if you know a drug addict. Never give them ANYTHING not even a single dollar. The second you give then something they're associate you with getting free stuff. And they will pester you to no end

  16. dave warner says:

    great summary

  17. UK man loves goddesses says:

    disliked in case he does a shitty jump scare like in the The Chemical Mind video

  18. Kathleen Rothery says:

    Good lmfo and well spoken but lot more vomplex and no mention of the devastion around addiction and no cure imfo but intresting topic thanx

  19. Aaron Slater says:

    I appreciated the tone and serious nature of this video. As an addict, this is one of the best videos to watch on addiction I've ever seen.

  20. Manuel Estape says:

    I definitely have a problem with pornography. Would you as an adult now has become exceedingly difficult to manage. I now recognize alcohol is a problem as well. What can I do to provide myself the regiment and the chemical response that my brain and body wants so bad. I have tried not doing it and giving it to urges and it makes me almost go into a panic. I can describe it as when your OCD and something's not being done their proper way and how you have like this itching in your brain and overall sickness it's not really physical but your mind wants it so bad it makes it that way. I just want to know how to beat whatever going on in my head cuz I actually want to stop

  21. DONT READ MY PROFILE PICTURE says:

    I was going to try and see what happens if I try to completely avoid overstimulating for a month, but like he said its nearly impossible and I lasted about a few days

  22. thewalrus says:

    Sooo, why aren't all chronic pain patients on opioid medication addicts? Keep in mind physical dependence is NOT the same as addiction.

  23. Author Marlon L. Dotson says:

    I almost killed my addict fiance because i tried to save her…Amazon.com/author/marlonldotson

  24. dralix says:

    nice dude very informative

  25. davesbabe42able says:

    This video was very helpful. Thank you very much!

  26. a l says:

    SciShow is my only addiction at this point…

  27. bearsemen says:

    I am addicted to masturbation

  28. Michael Espeland says:

    I thought ecstacy/MDMA played a bigger role in the release of Serotonin, not so much with Dopamine?

  29. Herb Tenderson says:

    I need dopamine always.

  30. Timothy Cousineau says:

    I'm a recovering meth and heroin addict, im 4 years clean in September 2018.

  31. Julie says:

    Amphetamine and methamphetamine are reuptake inhibitors via vesicle reversal as part of the release mechanism. To say cathiniones are the worst of both amphetamine and cocaine based on its mechanism is incorrect, as it has weaker release potential than amphetamine and all three stimulants are essentially NDRIs with different serotonin action.

    Do your own research kids.

  32. Fitness says:

    What he is saying is all garbage. Tolerance is caused by an increase in the receptor count not a reduction. This stuff is hard to fake buddy! He said alchohol binds with seratonin & acetylcholine I thought it binded with GABAa receptors?!

  33. Fitness says:

    Also listen to the way he speaks he's obviously ripping off the girl who runs the "How to ADHD" channel!

  34. Ron Brideau says:

    It is almost painful to see such an intelligent person misinformed on so many important points to serve malignant narcissism of a control freaking system.

  35. George Raul says:

    Could you please give me at least a little part of the bibliography used to back up this video …I need it for my Bachelor Thesis.

  36. devonzf says:

    You have beans within the mouth

  37. Valerie B says:

    Marry me.

  38. Tim Newman says:

    dude, i think you are a real life professor frink….

  39. Nightwing 08 says:

    I enjoy watching these videos almost to an addiction but close up footage just points out you are just reading the information and it bothers me for some reason. Losing that false reality that you personally know all this information idk its wierd.

  40. Nate Norris says:

    i only subscribe to a couple channels. this will be one forever.

  41. tora says:

    I have air addiction

  42. HusbandoAndWaifu says:

    The narrator guy sounds like Professor Frink from the Simpsons! Lol I kept waiting for him to say HOYVIN-GLAVIN!

  43. Samantha Scholl says:

    You should do a video on Xanax. A drug that shouldn't even exist, in my opinion. It's way too addictive to make its intended effects worth it when there are so many other anti-anxiety drugs out there

  44. Elaine McDonald says:

    Hank do you see comments, like this one, six years later?

  45. Darryl Learie says:

    I’m tired of addiction being constantly displayed as a single dimensional paradigm – in other words that compulsion/desire solely drives addiction.

    Withdrawal is a huge factor that drives many addictions like smoking cigarettes.

    For example, in the case of smoking cigarettes, the reward actually becomes very low to the point where smokers don’t even like smoking.

    But what keeps them hooked is the brutally uncomfortable withdrawal they experience if they do not follow up on that next cigarette.

    Your video very subtlety hinted at withdrawal but pretty much ignored the topic giving the impression that addiction is solely about compulsion.

  46. Loliebol Redwonder says:

    Is ge high?

  47. Lt Kelley says:

    You sound and look like you have a cold take care of yourself

  48. Sanad Benali says:

    always a pleasure great job

  49. Billy Bob Joe, The Professional Meme-ist says:

    "Inventing drugs"

    well, I don't know about that, finding a plant, eating it, and getting high isn't inventing anything. We have definitely synthesized many drugs, but that was well after discovering that eating certain naturally found substances alters one's consciousness. Many animals in the wild do just that; eat naturally found substances that alter their consciousness, and presumably, when they do this repeatedly, they know what they're doing and it's intentional. "Drugs" is such a wide umbrella- there are plenty of them that aren't artificial, you can find no shortage of natural drugs. And I don't think our brains are too smart for their own good- there's a reason we prescribe stuff that's basically cocaine (methylphenidate, sold as Ritalin or Concerta) and methamphetamine (amphetamine salts like dextroamphetamine that are sold as Adderall). For some of us, it helps. We prescribe the stuff we make scary TV shows (breaking bad) about to children. This stuff isn't as cut and dry as people want to make it. The truth is is that none of this is simple, and no matter how bad you may want to just say "meth is always bad" and leave it at that, it's just not true.

    "Don't do drugs"

    Okay, so if I have a cold, I shouldn't take ibuprofen? The obvious response is "Yeah yeah yeah, don't do psychoactive drugs, smart-alec".

    Okay, so someone with ADHD shouldn't take their meds? A bit disappointed to hear this black-and-white attitude towards the huge umbrella that is "drugs" out of Hank Green. This is why when someone once told me they wanted to try laughing gas at the dentists (when they got their wisdom teeth removed), they were surprised that it was a "drug". Or that the hospital will give you something pretty close to heroin. We need to quit telling young people with a prescription to celebrate being drug-free in school. These kids then feel above someone who takes nearly the same exact substance they do… it's not right. The way we talk about drugs and addiction just isn't right.

  50. H G says:

    this might sound weird.. but i think i’m addicted to MCQ questions if u think about it’s just like gambling ..( if u don’t know the answer) .. and ever near-misses just add to more gambling …. the answer need not to be correct but the chances of being right matters ….8:27

  51. Audrey says:

    You should do one about vaping. It’s a major trend among teens and I think it’s going to lead to problems in the future. Why spend money to get yourself addicted to nicotine if you don’t need it to quit smoking? It’s ridiculous

  52. WashHtsWarrior says:

    Its a little misleading to say synthetic cathinones combine the effects of meth and cocaine at the same time. Makes it sound like snorting coke and smoking meth is equivalent to taking bath salts… its not… its just not…

  53. Abundance America - Dude Legend says:

    I love this channel 🙂

  54. Drew Kosman says:

    ahha you have a sex show

  55. Sourav B says:

    ramen tastes so good after drinking

  56. Ranjit says:

    Wish you woulda done fentanyl.

  57. Psychedeloshippie says:

    Bath salts isn’t an amphetamine. It’s a Cathinone which have very similar effects to amphetamines.

  58. Abbas Sayid says:

    more picture and animation made it attractive video

  59. Abhijit Singh says:

    Baby making 😄

  60. ɮօʊռċɛ օʄʄ says:

    II is addicted to Crystal Meth

  61. undeadpresident says:

    Only drug worth using is psiloybin mushrooms. Non-addictive and actually helps in achieving a healthy psychological state.

  62. mountaingoat1003 says:

    Ibogaine interrupts addiction.

  63. oguzhan ince says:

    is he stoned :d

  64. vaxrvaxr says:

    I'm getting seasick watching this. Slow down dude! Stop waving your arms around!

  65. christian galicia says:

    You forgot to explain how weed works. Marihuana as its own mechanisms

  66. Joe Russo says:

    I always say, 'We all have our crack pipe to smoke.' For me its weight training, and shopping.

  67. Rob Rosen says:

    Might as well face it, you're addicted to love.

  68. Ankul Upreti says:

    Has anyone tried dmt ?

  69. Sorcha R says:

    We watched this in my Addictions class and it was really pretty helpful in clarifying some stuff.

  70. Sean Beasley says:

    I love how hard it is to tell a brand new scishow to one from 2012 just consistent epic quality for years! As someone just getting into it I'm loving that there is SO MUCH to binge on. Hope someone from the team gets the chance to read this so I can say thank you!

  71. MAtthew Dentistry says:

    Says "don't do drugs" like it's a joke 😏

  72. The End says:

    You should talk about Kratom. People believe that since it’s a plant that it’s safe. But that isn’t the truth since poppy plants exist and that can kill you.

    Edit- I also heard of something people smoke called angel trumpets. It’s euphoric and yet 1 out of 2 people die from it.

  73. Will Valerio says:

    watched this while smoking my thousandth "last cigarette"

  74. berni bern says:

    You talk way too fast, great content though, thanks

  75. Bdrsalm12 12 says:

    I have a prezination about addicts and what they feel and how they feel when they try to treat themselves I need addicts who communicate with me in Instagramm a.n.088 I hope one continues to addicted to the games habits of any thing and thank you

  76. darrick steele says:

    When I first started experimenting with getting high I used to say, "I'm doing drugs." But after a few years of abuse I changed my phrase to, "The drugs are doing me." Even Though at the time I thought this was a cute or cool inverted way to express my lost eccentric teenage mind, and it is a popular enough saying to have found itself in the lyrics of at least one pop culture rock song that I can think of (Marilyn Manson in case you have to know), it was probably more than just a teenager repeating what they heard on the radio.
    In hindsight I see an addict expressing concern for himself, and subconsciously asking for help with his unforeseen long dark road of being manipulated by the very thing that he thought was his ticket to freedom.✨🌈🌊🤔🔍🚑😒

    In nutshell… if you ever hear a teenager, or anyone for that matter, claim that "the drugs are doing him" (or her) … pay attention to it. They're most likely becoming addicted.

  77. Kanzu999 says:

    As it's said in the video, I'm very convinced that dopamine works more as a "wanting to do stuff" rather than feeling good or euphoric. I've tried cocaine a couple of times, and I always feel like I have the energy and motivation to accomplish anything. Any task can become interesting, and I'm very good at focusing on everything, because everything is more interesting, and I just have a whole lot of motivation.
    I've also tried laughing gas many times, and if I try to do some task while on the very short laughing gas high, it's very difficult to focus and accomplish anything. Incredibly, while I'm on cocaine as well, I can actually maintain my focus, maybe because I feel like whatever task I'm trying to do is just much more important than it would otherwise be.

  78. theD4Wdude says:

    MORE METH MORE MORE MORE

  79. BlackDeath60 8 says:

    cheers everyone

  80. Sensi Star says:

    Ugh boy I love ecstasy 💦💞💞
    It’s the only amphetamine I’ve ever tried. I haven’t done it in 3 years though lmao. I’m not stupid, I need my brain to keep working 😂

  81. Ardeshir Afshari says:

    i wonder if being addicted to studying is a good thing or a bad thing…

  82. the_tablecloth says:

    gahbah

  83. vishal kasture says:

    Your video was of utter importance. earlier although I read, watched and listened various source and info contents, I could not understand them better as I have now.
    Kudos to you for your efforts and thanx for enlightening us
    Keep bringing more of such videos
    They are highly fascinating and addictive😉

  84. Khaled Elmalky says:

    Hello, it's day one for me quitting heroin . https://youtu.be/cC5fM5gwUzo

  85. Jordan North says:

    Do a video of cannabis on the brain? Your videos are amazing x

  86. Mrigank says:

    Well Done

  87. A B says:

    Am I an addict? Omg

  88. JNeal134 says:

    I have a ridiculous behavioral addiction to the internet and gaming. I tried a 90 day detox to focus on my studies… didn't even last a week…

  89. LucidDose says:

    Don't do drugs? But we are drugs…

  90. Harden Thicke says:

    I'm sure at 4:00 is addiction defined.
    You now need to replace what you had naturally.

  91. Maverick Hargrave says:

    Funny he didn't mention that many of these drugs are prescribed by psychiatrists, and people use on a daily basis. I used a lot of Ritalin years ago, and had no idea how much it was influencing my brain.

  92. Anita Pezzi says:

    As a recovering drug addict with 6 years clean, I think it would be quite interesting if you did an episode about the recovery from drug addiction on a chemical level. What damage is repairable vs. what damage is not.

  93. Jazzbeee Tazzbeee says:

    Me: plays video game while listening to episode
    Hank: even with distractions viddo gamers will still play
    Me: puts controller down what video game? I wasnt playing any video game

  94. Catalina Ibarburu says:

    SSRI antidepressants work in the same way as cocaine in the dopamine and norepinephrine receptors so maybe i could make a switch you know (im just kidding dont do drugs)

  95. The Incarnate says:

    I got a drug and alcohol Treatment ad before watching this 😂

  96. Josh Guyette says:

    0:00 – Brain… Deliciously Amazing? OK Hannibal Lector. lol

  97. Carhy nuit says:

    Matthew 11:28-30 King James Version (KJV)

    28 Come unto me, all ye that labour and are heavy laden, and I will give you rest.

    29 Take my yoke upon you, and learn of me; for I am meek and lowly in heart: and ye shall find rest unto your souls.

    30 For my yoke is easy, and my burden is light

  98. bernardo montero says:

    you didnt say anything about weed.. means is not that bad??

  99. Rajat Makwana says:

    He sounded like he was high.

  100. Non Ya says:

    Who else tried to scratch his neck mole off there screen?

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